Noninvasive Monitoring of Cardiac Preload and Contractility by Heart Beat-Derived Mechanical Vibration on the Chest Wall in Guinea Pigs

Takeshi Adachi, Takayoshi Ohba, Susumu Fujisawa, Kyoichi Ono

Abstract


Background: Myocardial motion produces compression waves that are transmitted to the surface of the chest and vibrate the chest wall. Piezoelectric transducers, which detect mechanical vibrations, may be useful for evaluating cardiac and/or breathing movements when the sensor is placed under an animal’s body.

Methods: We assessed heartbeat-related chest vibration signals (CVS) detected with a piezoelectric transducer in anesthetized guinea pigs while simultaneously monitoring the electrocardiogram, heart sounds, aortic pressure, and central venous pressure.

Results: CVS displayed characteristic features as the ventricle and/or atrium contracted and relaxed during cardiac cycles. A transient positive wave, which occurred approximately at the onset of the R wave on the electrocardiogram, was followed by a profound negative wave during systole. The negative wave peaked early in systole and then gradually returned. A small notch was observed at the second heart sound. A dome-shaped positive wave was observed during diastole that connected to the transient positive wave of the next cardiac cycle. In response to phlebotomy (blood volume, 15 ml/kg), the size of the dome-shaped positive wave decreased, whereas saline transfusion (20 ml/kg) increased the positive wave during diastole. Administration of isoproterenol markedly increased the transient positive wave at the onset of systole, whereas phenylephrine affected the transient positive wave only slightly.

Conclusions: Our findings suggest that CVS may be useful to identify cardiac cycles and to evaluate cardiovascular dynamics during changes in blood volume and/or cardiac contractility.


Full Text:

PDF

References


Pinsky MR. Functional haemodynamic monitoring. Curr Opin Crit Care 2014;20:288-93. doi: 10.1097/MCC.0000000000000090.

Hollenberg SM. Hemodynamic monitoring. Chest 2013;143:1480-8. doi: 10.1378/chest.12-1901.

Romero-Bermejo FJ, Ruiz-Bailen M, Guerrero-De-Mier M, Lopez-Alvaro J. Echocardiographic hemodynamic monitoring in the critically ill patient. Curr Cardiol Rev 2011;7:146-56.

Marik PE, Baram M, Vahid B. Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares. Chest 2008;134:172-8. doi: 10.1378/chest.07-2331.

Jain PK, Tiwari AK. Heart monitoring systems—A review. Computers in Biology and Medicine 2014;54:1-13. doi: 10.1016/j.compbiomed.2014.08.014.

Bayevski RM, Egerov AD, Kasajan LA. Seismocardiography. Kardiologiia 1964;18:87-9

Zanetti JM, Tavakolian K. Seismocardiography: past, present and future. Conf Proc IEEE Eng Med Biol Soc 2013;2013:7004-7. doi: 10.1109/EMBC.2013.6611170.

Sato S, Yamada K, Inagaki N. System for simultaneously monitoring heart and breathing rate in mice using a piezoelectric transducer. Med Biol Eng Comput 2006;44:353-62.

Sato S, Ishida-Nakajima W, Ishida A, et al. Assessment of a new piezoelectric transducer sensor for noninvasive cardiorespiratory monitoring of newborn infants in the NICU. Neonatology 2010;98:179-90. doi: 10.1159/000283994.

Sato S. Quantitative evaluation of ontogenetic change in heart rate and its autonomic regulation in newborn mice with the use of a noninvasive piezoelectric sensor. Am J Physiol Heart Circ Physiol 2008;294:H1708-15. doi: 10.1152/ajpheart.01122.2007.

Adachi T, Shibata S, Okamoto Y, et al. The mechanism of increased postnatal heart rate and sinoatrial node pacemaker activity in mice. J Physiol Sci 2013;63:133-46. doi: 10.1007/s12576-012-0248-1.

Scarborough WR, Talbot SA. Proposals for ballistocardiographic nomenclature and conventions: revised and extended report of Committee on Ballistocardiographic Terminology. Circulation 1956;14:435-50.

Vogt E, MacQuarrie D, Neary JP. Using ballistocardiography to measure cardiac performance: a brief review of its history and future significance. Clin Physiol Funct Imaging 2012;32:415-20. doi: 10.1111/j.1475-097X.2012.01150.x.

Ovadia M, Gear K, Thoele D, Marcus FI. Accelerometer systolic time intervals as fast-response sensors of upright posture in the young. Circulation 1995;92:1849-59.

Tavakolian K, Portacio G, Tamddondoust NR, et al. Myocardial contractility: a seismocardiography approach. Conf Proc IEEE Eng Med Biol Soc 2012;2012:3801-4. doi: 10.1109/EMBC.2012.6346795.

Marcus FI, Sorrell V, Zanetti J, et al. Accelerometer-derived time intervals during various pacing modes in patients with biventricular pacemakers: comparison with normals. Pacing Clin Electrophysiol 2007;30:1476-81.

Korzeniowska-kubacka I, Bili M, Piotrowicz R. Usefulness of Seismocardiography for the Diagnosis of Ischemia in Patients with Coronary Artery Disease. Ann Noninvasive Electrocardiol 2005;10(3):281-7.

Becker M, Roehl AB, Siekmann U, et al. Simplified detection of myocardial ischemia by seismocardiography. Differentiation between causes of altered myocardial function. Herz 2014;39(5):586-92. doi: 10.1007/s00059-013-3851-x.

Kozek-Langenecker SA, Afshari A, Albaladejo P, et al. Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology. Eur J Anaesthesiol 2013;30:270-382. doi: 10.1097/EJA.0b013e32835f4d5b.

Tavakolian K, Dumont GA, Houlton G, Blaber AP. Precordial vibrations provide noninvasive detection of early-stage hemorrhage. Shock 2014;41:91-6. doi: 10.1097/SHK.0000000000000077.

Rickards AF, Bombardini T, Corbucci G, Plicchi G. An implantable intracardiac accelerometer for monitoring myocardial contractility. Pacing Clin Electrophysiol 1996;19:2066-71.

Bombardini T, Marcelli E, Picano E, et al. Operator independent left ventricular function monitoring during pharmacological stress echo with the new peak transcutaneous acceleration signal. Heart 2001;85:286-9.

Gemignani V, Bianchini E, Faita F, et al. Transthoracic sensor for noninvasive assessment of left ventricular contractility: validation in a minipig model of chronic heart failure. Pacing Clin Electrophysiol 2010;33:795-803. doi: 10.1111/j.1540-8159.2009.02684.x.

Shewan LG, Coats AJS, Henein M. Requirements for ethical publishing in biomedical journals. International Cardiovascular Forum Journal 2015;2:2. DOI: 10.17987/icfj.v2i1.4.




DOI: https://doi.org/10.17987/jatamis.v1i0.207

Refbacks

  • There are currently no refbacks.


Copyright (c) 2016 Takeshi Adachi, Takayoshi Ohba, Susumu Fujisawa, Kyoichi Ono

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

ISSN: 2518-6140 (on-line version)