Statins Plus Metformin: a Promising Combination for Prevention and Treatment of Atherosclerosis

Fei Luo, Yuan Guo, Xiang-ping Li


Statins are the cornerstone for primary and secondary prevention of atherosclerosis. But statin monotherapy in some patients will not be sufficient to achieve an LDL-C target and increase the incidence of new-onset diabetes in a dose dependent manner, especially in women, elderly, presence of family history of type 2 diabetes and Asian ethnicity. Recently metformin, an old and effective antidiabetic medication, has been found to reduce LDL-C levels and has cardiac benefits for patients with T2D. Therefore, statins plus metformin may further reduce LDL-C levels and partly counteract statin-induced diabetes.

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ISSN: 2518-6140 (on-line version)