Pharmacological Use of NLRP3 Inflammasome Inhibitors: Novel Intervention Strategies in Diabetes-Associated Vascular Complications

Mi-Hua Liu, Xiao-Long Lin

Abstract


NLRP3 inflammasome has emerged as a key regulator of glucose and insulin homeostasis. Several studies have shown that activation of the NLRP3 inflammasome contributes to obesity-induced inflammation and insulin resistance . Increased oxidative stress may also contribute to NLRP3 inflammasome activation during diabetes and its complications . Therefore, selective inhibition of NLRP3 inflammasome is a promising target to prevent diabetes and slow down the progression of its complications.

References


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DOI: https://doi.org/10.17987/jatamis.v2i0.371

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Copyright (c) 2017 Mi-Hua Liu, Xiao-Long Lin

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ISSN: 2518-6140 (on-line version)